USM defeated DePaul in 75-68 Wednesday night to kick off the CBE Hall of Fame Classic.
Junior forward Aaron Brown led Southern Miss with 13 points. Senior forward Daveon Boardingham added 12 points and seven rebounds while Michael Craig scored 12 points with eight rebounds.
Brandon Young led DePaul with 23 points and six rebounds. He was the only other Blue Demon in double figures with 16 points.
Southern Miss will travel to North Dakota for their next matchup against North Dakota State. The Bisons are coming off an impressive 24-10 season which led to a berth in the CBI Tournament, but they lost in the first round.
The game will be Nov. 18 at 7 p.m.